Lipid class

Dihexosylceramide

Description
placeholder: The dihexosylceramides are a subclass of glycosphingolipids, characterized by the presence of two hexose sugars linked to a ceramide backbone. Specifically, they consist of a sphingosine or dihydrosphingosine base, an amide-linked fatty acid, and two hexose residues, typically galactose or glucose, attached to the 1-hydroxyl group of the sphingoid base. This unique structure enables dihexosylceramides to play a crucial role in modulating immune responses, particularly in the context of antigen presentation and T cell activation. They have been shown to interact with CD1d molecules on antigen-presenting cells, facilitating the presentation of lipid antigens to NKT cells and influencing the subsequent immune response. Additionally, dihexosylceramides have been implicated in the regulation of inflammatory responses, with evidence suggesting they can modulate cytokine production and immune cell trafficking.
Example 2D structure
An example of the Dihexosylceramide (40:0) species (C52H101NO13).
Image of the 2D molecular structure of an example member of the Dihexosylceramide lipid class. Image of the 2D molecular structure of an example member of the Dihexosylceramide lipid class.
Dihexosylceramide class lipid.
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Dihexosylceramide lipid species
Sorted by: molecular weight
Molecular formula Lipid species Molecular weight (g/mol) "Isoform specificity"
CD1a CD1b CD1c CD1d
C52H101NO13 Dihexosylceramide (40:0) 970.72
C54H99NO13 Dihexosylceramide (42:3) 992.7
C54H101NO13 Dihexosylceramide (42:2) 994.72
C54H103NO13 Dihexosylceramide (42:1) 996.73
C54H105NO13 Dihexosylceramide (42:0) 998.75
placeholder: Only lipid species which could be unambigously determined experimentally are shown.

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