Lipid class

Ether-phosphatidylethanolamine

Description
placeholder: The ether-phosphatidylethanolamine (ePE) class of lipids is a subset of glycerophospholipids characterized by the presence of an ether linkage between the glycerol backbone and the fatty acid chain. Specifically, ePEs feature a 1-O-alkyl ether bond at the sn-1 position, in contrast to the ester bond found in traditional phosphatidylethanolamines. This unique structural feature confers distinct biophysical properties, including increased resistance to phospholipase A2-mediated hydrolysis and altered membrane fluidity. Functionally, ePEs have been implicated in various cellular processes, including membrane trafficking, signal transduction, and the regulation of inflammatory responses. Notably, ePEs have been shown to play a role in the presentation of antigens to T-cells, highlighting their importance in the context of immune function.
Example 2D structure
An example of the Ether-phosphatidylethanolamine (38:7) species (C43H74NO7P).
Image of the 2D molecular structure of an example member of the Ether-phosphatidylethanolamine lipid class. Image of the 2D molecular structure of an example member of the Ether-phosphatidylethanolamine lipid class.
Ether-phosphatidylethanolamine class lipid.
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Ether-phosphatidylethanolamine lipid species
Sorted by: molecular weight
Molecular formula Lipid species Molecular weight (g/mol) "Isoform specificity"
CD1a CD1b CD1c CD1d
C43H74NO7P Ether-phosphatidylethanolamine (38:7) 748.53
C43H78NO7P Ether-phosphatidylethanolamine (38:5) 752.56
C45H78NO7P Ether-phosphatidylethanolamine (40:7) 776.56
C47H88NO7P Ether-phosphatidylethanolamine (42:4) 832.62
placeholder: Only lipid species which could be unambigously determined experimentally are shown.

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