Lipid class

Ether-phosphatidylcholine

Description
placeholder: The ether-phosphatidylcholine class of lipids, also known as plasmalogens, is a unique subset of phospholipids characterized by an ether linkage between the glycerol backbone and the fatty acid chain. Specifically, the sn-1 position of glycerol is linked to a fatty acid via an ether bond, whereas the sn-2 position is esterified to a fatty acid. This distinctive structure confers unique biophysical properties, including increased fluidity and resistance to oxidation. Functionally, plasmalogens are enriched in immune cells, where they play a crucial role in modulating inflammatory responses and antigen presentation. They have been implicated in the regulation of immune cell signaling, particularly in the context of T cell activation and cytokine production. Additionally, plasmalogens have been shown to influence the organization and function of lipid rafts, specialized membrane microdomains that facilitate immune cell signaling and activation. Overall, the ether-phosphatidylcholine class of lipids plays a critical role in modulating the immune response and maintaining immune homeostasis.
Example 2D structure
An example of the Ether-phosphatidylcholine (30:1) species (C38H76NO7P).
Image of the 2D molecular structure of an example member of the Ether-phosphatidylcholine lipid class. Image of the 2D molecular structure of an example member of the Ether-phosphatidylcholine lipid class.
Ether-phosphatidylcholine class lipid.
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Ether-phosphatidylcholine lipid species
Sorted by: molecular weight
Molecular formula Lipid species Molecular weight (g/mol) "Isoform specificity"
CD1a CD1b CD1c CD1d
C38H76NO7P Ether-phosphatidylcholine (30:1) 690.54
C40H80NO7P Ether-phosphatidylcholine (32:1) 718.57
C40H82NO7P Ether-phosphatidylcholine (32:0) 720.59
C42H82NO7P Ether-phosphatidylcholine (34:2) 744.59
C42H84NO7P Ether-phosphatidylcholine (34:1) 746.61
C42H86NO7P Ether-phosphatidylcholine (34:0) 748.62
C44H80NO7P Ether-phosphatidylcholine (36:5) 766.57
C44H82NO7P Ether-phosphatidylcholine (36:4) 768.59
C44H90NO7P Ether-phosphatidylcholine (36:0) 776.65
C46H82NO7P Ether-phosphatidylcholine (38:6) 792.59
C44H86NO7P Ether-phosphatidylcholine (36:2) 794.6
C46H86NO7P Ether-phosphatidylcholine (38:4) 796.62
C46H88NO7P Ether-phosphatidylcholine (38:3) 820.62
C48H86NO7P Ether-phosphatidylcholine (40:6) 820.62
C48H88NO7P Ether-phosphatidylcholine (40:5) 822.64
C50H88NO7P Ether-phosphatidylcholine (42:7) 846.64
C50H90NO7P Ether-phosphatidylcholine (42:6) 848.65
C50H92NO7P Ether-phosphatidylcholine (42:5) 850.67
C48H96NO7P Ether-phosphatidylcholine (40:1) 852.68
C50H94NO7P Ether-phosphatidylcholine (42:4) 852.68
C50H98NO7P Ether-phosphatidylcholine (42:2) 856.72
C52H96NO7P Ether-phosphatidylcholine (44:5) 878.7
placeholder: Only lipid species which could be unambigously determined experimentally are shown.

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